NALT (N-Acetyl-L-Tyrosine) vs. L-Tyrosine
which is superior?
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Many companies will put NALT (N-Acetyl-L-Tyrosine) as opposed to pure L-Tyrosine in pre-workout supplements claiming that it is the superior form of the amino acid. Many claim that it is more effective and bioavailable than standard L-Tyrosine supplementation. But is that entirely true? Many studies say otherwise. Tyrosine is considered an essential amino acid, it is used in the body as a precursor to the neurotransmitters: dopamine, norepinephrine, and epinephrine. NALT is L-Tyrosine bonded to an acetyl group to increase water solubility. It is thought that increased water solubility leads to increased bioavailability. While it is true that NALT mixes better in water than L-Tyrosine, the bioavailability piece does not appear to be true. In the case of NALT vs L-Tyrosine, NALT is not more bioavailable than pure L-Tyrosine. A single dose of 100mg L-tyrosine can elevate plasma tyrosine levels for up to 7 hours. [1] At a dosage of 100mg/kg, oral tyrosine supplement (powders/pills) has been shown to increase plasma tyrosine concentrations by: Multiple studies have compared NALT to these findings and found that NALT only increases plasma Tyrosine levels by 25% and another study found that no plasma tyrosine increase. If that isn't enough to end the discussion on NALT vs. L-Tyrosine supplementation, a study on mice found that NAT (NALT) does not cross the BBB (blood brain barrier) better than L-tyrosine and in fact was the least effective form of the four forms of tyrosine tested.
In conclusion, pure L-Tyrosine is the the superior form of Tyrosine. NALT (N-Acetyl-L-Tyrosine) may be more water soluble, but it does not cross the blood brain barrier efficiently. and many companies are misleading you to believe that they are using the superior form, when in fact it is not increasing plasma tyrosine levels and may be the least effective form of the amino acid.
Many companies will put NALT (N-Acetyl-L-Tyrosine) as opposed to pure L-Tyrosine in pre-workout supplements claiming that it is the superior form of the amino acid. Many claim that it is more effective and bioavailable than standard L-Tyrosine supplementation. But is that entirely true? Many studies say otherwise. Tyrosine is considered an essential amino acid, it is used in the body as a precursor to the neurotransmitters: dopamine, norepinephrine, and epinephrine. NALT is L-Tyrosine bonded to an acetyl group to increase water solubility. It is thought that increased water solubility leads to increased bioavailability. While it is true that NALT mixes better in water than L-Tyrosine, the bioavailability piece does not appear to be true. In the case of NALT vs L-Tyrosine, NALT is not more bioavailable than pure L-Tyrosine. A single dose of 100mg L-tyrosine can elevate plasma tyrosine levels for up to 7 hours. [1] At a dosage of 100mg/kg, oral tyrosine supplement (powders/pills) has been shown to increase plasma tyrosine concentrations by: Multiple studies have compared NALT to these findings and found that NALT only increases plasma Tyrosine levels by 25% and another study found that no plasma tyrosine increase. If that isn't enough to end the discussion on NALT vs. L-Tyrosine supplementation, a study on mice found that NAT (NALT) does not cross the BBB (blood brain barrier) better than L-tyrosine and in fact was the least effective form of the four forms of tyrosine tested.
In conclusion, pure L-Tyrosine is the the superior form of Tyrosine. NALT (N-Acetyl-L-Tyrosine) may be more water soluble, but it does not cross the blood brain barrier efficiently. and many companies are misleading you to believe that they are using the superior form, when in fact it is not increasing plasma tyrosine levels and may be the least effective form of the amino acid.